1.      “GABAergic Agents to Treat Memory Deficits (A),” Cook, James M.; Han, D.; and Clayton, T.;  Provisional patent filed June 30, 2005. Published in 2006. Patent No. PCT/US 2006018721; US Patent No. 7,595,395; issued July 24, 2009.

2.      “GABAergic Agents to Treat Memory Deficits (B),” Cook, J.M., Clayton, T., Teng Johnson, Y., Rallapalli, S., Han, D., Provisional patent filed August 31, 2009. Published May 27, 2010. Publication number US20100130479 A1.

3.       “GABAergic Receptor Subtype Selective Ligands and Their Uses,” J.M. Cook, T. Clayton, H. Jain, Y. Teng, J. Yang, S. Rallapalli, Filed a provisional patent on May 4, 2008.

4.      “Printing Using Color Changeable Material,” Barndt, J.A.; Barton, R.H.; Clayton, T.S.; Rose, M.J.; Volz, P.G. WO 2009/094063 A1. Published July 30, 2009.

5.      “Ablative Printing,” Graushar, W.T; Barndt, J.A.; Barton, R.H.; Clayton, T.S..; US 2009/0128860 A1; Published May 21, 2009.

6.       “Device, Method, and Composition for Reducing the Incidence of Tobacco Smoking,” Roth, B.; Clayton, T. U.S. Pat.  7,766,018; August 03, 2010.

7.      “Gabaergic Receptor Subtype Selective Ligands and their Uses,” Cook, J. M., S. Rallapalli, T. Clayton, H. Jain, J. Yang, Teng, Y., provisional patent filed on April 28, 2011. Application No. 6147899.

8.      “System and Method for Adding Data to a Printed Publication,” Graushar, W., Barndt, J., Barton, R., Clayton, T. Filed on November 20, 2008.  US Pat. No. 8,120,81.  Patent issued February 21, 2012.

9.      GABAergic Receptor Subtype Selective Ligands and their uses, “Cook, J. M., Clayton, T., Jain, H.D., Rallapalli, S. K., Johnson, Y. T.,Yang, J.,Poe, M.M., Namjoshi, O. A., Wang, Z. Patent publication no US 2012/0295892 A1, Published November 22nd, 2012.

10.   “Scented Thermochromic Ink,” Clayton, T., Owen, T., filed May 14, 2012, WO2012158611A1and US 20120315412 A1.

11.   “Thermochromic Level Indicator.” Clayton, T., Owen, T., U.S. Patent Application Serial No. 61/663,089, filed on June 22, 2012.

12.   “Variable Printing of Thermochromic Codes,” Clayton, T., PCT/US2012/051941, filed August 22, 2012.

13.   “Stabilizing Additives for Thermochromic Pigments,” Owen, T., Clayton, T., Tomovich, V., Roberts, C., Siske, B.,  U.S. Provisional Patent Application No. 61/747,004, filed on December 28, 2012.

14.   “Reversible Thermochromic and Photochromic Ink Pens and Markers,” Clayton, T.; Owen, T., U.S. Patent Application Serial No. 61/605,714 on March 01, 2012 and U.S. Patent Application Serial No. 13/782,611 and PCT/US13/20814, filed January 9, 2013.

15.   “Thermochromic Coloring Pad,” Clayton, T.; Owen, T., U.S. Patent Application Serial No. 13/752,056, filed on January 28, 2013.

16.   “Pressure Sensitive Coating for Image Forming,” Clayton, T., Owen, T., U.S. Patent Application Serial No. 61/732,120 on November 30, 2012 and U.S. Patent Application Serial No. 61/584,398 on January 9, 2012, and U.S. Patent Application No. 13/737,728 and PCT/US13/28555, filed March 1, 2013.

17.   “Small Scale Microencapsulated Pigments and Uses Thereof,” Clayton, T. U.S. Patent Application No. 13/843,492, filed on March 15, 2013.

18.   “Thermal Treatment to Improve Performance of Thermally Damaged Thermochromic Systems,” Clayton, T., Owen, T., U.S. Patent Application No. 61/832,039, filed on June 6, 2013.

19.   “Water-Activated Thermochromic Materials,” Clayton, T., Owen, T., U.S. Patent Application No. 61/836,563, filed on June 18, 2013.

20.   “Yellow Thermochromic Dyes and Ink Composition,” Clayton, T., Owen, T., Small, L., Wang, R., Du, Y., Abraha, M., U.S. Patent Application No. 61/842,165, filed on July 2nd, 2013.

21.   “Radiation Curable Ink Compositions,” Cong, L., Clayton, T., U.S. Patent 9,540,531 B2.  Patent issued January 10, 2017.

22.   “Gabaergic Receptor Subtype Selective Ligands and Their Uses,” Cook, J., Clayton, T. et al. U.S. Patent 9,597,342.  Patent issued March 21, 2017.

23.   “Thermochromic Efficiency Indicator,” Edson, P., Owen, T., Clayton, T., U.S. Patent 10,113,920.  Patent issued October 30, 2018.

24.   “Spot Gloss and Gloss Control in an Inkjet Printing System,” Cong, L., Clayton, T., U.S. Patent 10,730,318 B2.  Patent issued Aug. 4, 2020.


- Plato -

“Necessity is the Mother of Invention”



1.    “An Updated Unified Pharmacophore Model of the Benzodiazepine Binding Site on γ – Aminobutyric AcidA Receptors: Correlation with Comparative Models,” T. Clayton, J. Chen, M. Ernst, L.Richter, B.A. Cromer, C.J. Morton, H.Ng, C. Cook – Kaczorowski, F.J. Helmstetter, R. Furtmüeller, G. Ecker, M.W. Parker, W. Sieghart and J.M. Cook, Curr. Med. Chem., 14, 2755-2775 (2007).

2.    “Are GABAA Receptors Containing α5 Subunits Contributing to the Sedative Properties of α5 Agonists?” M. Savic, S. Huang, R. Furtmueller, T. Clayton, S. Huck, D. Obradovic, N. Ugresic, W. Sieghart, D. Bokonjic and J. M. Cook, Neuropsychopharmacology, 33, 332-339 (2008).

3.   “PWZ-029, a Compound with Moderate Inverse Agonist Functional Selectivity at GABAA Receptors Containing Alpha 5 Subunits, Improves Passive, but not Active, Avoidance Learning in Rats,” M. Savic, T. Clayton. R. Furtmueller, I. Gaurilovic, J. Samardzic, S. Savic, W. Sieghart and J.M. Cook, Brain Res., 1208, 150-159 (2008).

4.    “Selective Influence on Contextual Memory: Physiochemical Properties Associated with Selectivity of Benzodiazepine Ligands at GABA(A) Receptors Containing the α5 Subunit,” D. Harris, T. Clayton, J. Cook, R.Halliwell, P. Sahbaie, W. Sieghart, R. Furtmueller, and T. DeLorey, J. Med. Chem., 51, 3788-3803 (2008).

5.    “A Study of the Structure-activity Relationship of GABAA-benzodiazepine Receptor Bivalent Ligands by Conformational Analysis with Low Temperature NMR and X-ray Analysis,” Han, D.; Forsterling, H.; Li, X.; Deschamps, J.; Parrish, D.; Cao, H.; Rallapalli, S.; Clayton, T.; Teng, Y.; Majumder, S.; Sankar, S.; Roth, B.; Sieghart, W.; Furtmuller, R.; Rowlett, J.; Weed, M.; Cook, J., Bioorg. and Med. Chem., 16, 8853-8862 (2008).

6.   “Glutamatergic and GABAergic Modulations of Ultrasonic Vocalizations During Maternal Separation Distress in Mouse Pups,” Takahashi, A.; Yap, J.J.; Bohager, D.Z.; Faccidomo, S.; Clayton, T.; Cook, J.M.; Miczek, K.A., Psychopharmacol. (Berlin, Ger.) , 204, 61-71 (2009).

7.   “The Differential Role of α1 and α5 – Containing GABA(A) Receptors in Mediating Diazepam Effects on Spontaneous Locomotor Activity and Water-Maze Learning and Memory in Rats”, M. Savic, M. Milinkovic, S. Rallapalli, T. Clayton Sr., S. Joksimovic, M. Van Linn, J. M. Cook, Neuropsychopharmacology, 12, 1179-1193 (2009).

8.   “Novel Positive Allosteric Modulators of GABA(A) Receptors: Do Subtle Differences in Activity at Alpha 1 Plus Alpha 5 Versus Alpha 2 Plus Alpha 3 Subunits Account for Dissimilarities in Behavioral Effects in Rats”, M Savic, S. Majumder, S.Huang, R. Edwankar, R. Furtmuller, S. Joksimovic, T. Clayton, J. Ramerstovfer, M. Milinkovk, B. Roth, W. Sieghart, J. M. Cook, Progress in Neuro-Psychopharmacology and Behavioral Psychiatry, 34, 376-386 (2010).

9.   “Synthesis, Pharmacological Studies and Molecular Modeling of Some Tetracyclic 1,3 – Diazepinium Chlorides,” J, -A. Grant, T. Bonnick, M. Gossell- Williams, T. Clayton, J. M. Cook, Yvette Jackson, Biorg. Med. Chem., 18, 909-921 (2010).

10.   “Design, Synthesis and Subtype Selectivity Effects of 3,6-Disubstituted Beta Carbolines at Bz/GABA(A)ergic Receptors. SAR and Studies Directed Toward Agents for Treatment of Alcohol Abuse,” Yin, W., Majumder, S., Clayton, T., Petrou, S., VanLinn, M., Ma, C., June, H.L., Cromer, B.A., Roth, B.L., Luddens, H., Cook, J.M.  Bioorg and Med. Chem., 21, 7548-7564 (2010).

11.   “Part I. Unified pharmacophore protein models of the benzodiazepine receptor subtypes. Part II. Subtype selective ligands for alpha5 Gaba(A) /BZ receptors,” Clayton, T. Dissertation, University of Wiscosin-Milwaukee, Milwaukee, WI. (2011).

12.   “Modulation of the Reinforcing Effects of Ethanol in Rhesus Monkeys by a5 GABA (A) Receptor-Selective Ligands,” Rüedi-Bettschen, D.; Rowlett, J. K.; Rallapalli, S.; Clayton, T.; Cook, J. M.; Platt, D. M., Alcohol Clinical and Experimental Research, 37, (4), 624-634, (2013).

13.   “Allosteric Modulation of GABA (A) Receptors Compared to Non-GABAergic Compounds: Effects on Visuo Spatial Memory in Rhesus Monkeys”, P. Soto, N. Ator, S. Rallapalli, P. Biawat, T. Clayton, C. Brayton, J. Cook, M. Weed., Neuropsychopharmacology, 38, 2315-2325 (2013).

14.   “Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model”, Clayton, T., Poe, M., Rallapalli, R., Biawat, P., Savic, M., Rowlett, J., Cook, J.M., manuscript in preparation.

“A Protein Homology Model and Key Residues Identified in the Allosteric GABA(A) Benzodiazepine Receptor”, Clayton, T., manuscript in preparation.

15.   Clayton, T.; Poe, M.; Rallapalli, S.; Biawat, P.; Savic, M.; Rowlett, J.; Gallos, G.; Emala, C.; Kaczorowski, C.; Stafford, D.; Arnold, L.; Cook, J. Prime Archives in Chemistry. 2020. Vide Leaf Publishing. (Book Chapter)